GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11733284 | 1 | rs13125949 | chr4:48026560 | CNGA1 | chr4:47937996-48018610:- | 0.22 | 7.55 | 9.55E-14 | Renal underexcretion gout;Gout |
| BRCA | cis | rs11733284 | 1 | rs13125949 | chr4:48026560 | NIPAL1 | chr4:48018791-48039078:+ | 0.1 | 3.47 | 0.000532 | Renal underexcretion gout;Gout |
| BRCA | cis | rs7692995 | 1 | rs13127416 | chr4:17976779 | NCAPG | chr4:17812525-17846485:+ | 0.1 | 4.42 | 1.08E-5 | Height |
| BRCA | cis | rs1364989 | 1 | rs13131948 | chr4:55012652 | FIP1L1 | chr4:54243820-54326102:+ | -0.19 | -4.18 | 3.2E-5 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs7692995 | 1 | rs13132994 | chr4:17990181 | NCAPG | chr4:17812525-17846485:+ | 0.1 | 4.48 | 8.33E-6 | Height |
| BRCA | cis | rs7694379 | 1 | rs13133311 | chr4:88217223 | HSD17B11 | chr4:88257691-88312455:- | 0.11 | 3.93 | 9.19E-5 | Platelet count |
| BRCA | cis | rs1364989 | 1 | rs13133638 | chr4:55007426 | FIP1L1 | chr4:54243820-54326102:+ | -0.16 | -3.46 | 0.000566 | Lupus nephritis in systemic lupus erythematosus |
| BRCA | cis | rs4691139 | 1 | rs13134489 | chr4:165889437 | TRIM61 | chr4:165875600-165898818:- | 0.25 | 7.85 | 9.85E-15 | Ovarian cancer in BRCA1 mutation carriers |
| BRCA | cis | rs4864809 | 1 | rs13134680 | chr4:54527026 | LNX1 | chr4:54326439-54518682:- | 0.13 | 3.6 | 0.000336 | Beard thickness |
| BRCA | cis | rs6852678 | 1 | rs13136090 | chr4:76534792 | G3BP2 | chr4:76567955-76598667:- | -0.12 | -4.04 | 5.73E-5 | Magnesium levels |
| BRCA | cis | rs11733284 | 1 | rs13140968 | chr4:48025095 | CNGA1 | chr4:47937996-48018610:- | 0.23 | 7.8 | 1.46E-14 | Renal underexcretion gout;Gout |
| BRCA | cis | rs11733284 | 1 | rs13140968 | chr4:48025095 | NIPAL1 | chr4:48018791-48039078:+ | 0.11 | 3.62 | 0.000305 | Renal underexcretion gout;Gout |
| BRCA | cis | rs7694379 | 1 | rs13142655 | chr4:88195494 | HSD17B11 | chr4:88257691-88312455:- | 0.13 | 4.85 | 1.44E-6 | Platelet count |
| BRCA | cis | rs11733284 | 1 | rs13142905 | chr4:48025298 | CNGA1 | chr4:47937996-48018610:- | 0.22 | 7.53 | 1.04E-13 | Renal underexcretion gout;Gout |
| BRCA | cis | rs11733284 | 1 | rs13142905 | chr4:48025298 | NIPAL1 | chr4:48018791-48039078:+ | 0.1 | 3.47 | 0.000536 | Renal underexcretion gout;Gout |